Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model

Abstract

Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.

Keywords: Accelerated ion beam; Animal model; Brain radiation necrosis; Local volume irradiation; Spread-out Bragg peak.