Abstract
In this issue of Blood, Karol et al establish a link between glutamate receptor polymorphisms and osteonecrosis, using a large discovery cohort and 2 validation cohorts. One validation cohort included patients under treatment of acute lymphoblastic leukemia (ALL) and the second is patients receiving glucocorticoid treatment of various other indications.
MeSH terms
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Biomarkers / metabolism*
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Dexamethasone / adverse effects*
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Female
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Glucocorticoids / adverse effects*
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Humans
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Male
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Osteonecrosis / genetics*
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Polymorphism, Single Nucleotide / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Receptors, N-Methyl-D-Aspartate / genetics*
Substances
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Biomarkers
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Glucocorticoids
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Receptors, N-Methyl-D-Aspartate
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Dexamethasone