ALL and osteonecrosis

Blood. 2015 Oct 8;126(15):1734-5. doi: 10.1182/blood-2015-08-665067.

Abstract

In this issue of Blood, Karol et al establish a link between glutamate receptor polymorphisms and osteonecrosis, using a large discovery cohort and 2 validation cohorts. One validation cohort included patients under treatment of acute lymphoblastic leukemia (ALL) and the second is patients receiving glucocorticoid treatment of various other indications.

Publication types

  • Comment

MeSH terms

  • Biomarkers / metabolism*
  • Dexamethasone / adverse effects*
  • Female
  • Glucocorticoids / adverse effects*
  • Humans
  • Male
  • Osteonecrosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Receptors, N-Methyl-D-Aspartate / genetics*

Substances

  • Biomarkers
  • Glucocorticoids
  • Receptors, N-Methyl-D-Aspartate
  • Dexamethasone