Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

Chem Commun (Camb). 2015 Dec 11;51(95):16980-3. doi: 10.1039/c5cc06143a.

Abstract

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Delivery Systems
  • Esters / chemistry
  • Esters / radiation effects
  • Fluoresceins / chemistry
  • Fluorescent Dyes / chemistry
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Mice
  • Nanoparticles / chemistry
  • Nanoparticles / radiation effects*
  • Nylons / chemistry
  • Nylons / radiation effects*
  • Oxazines / chemistry
  • Photolysis
  • RAW 264.7 Cells

Substances

  • Esters
  • Fluoresceins
  • Fluorescent Dyes
  • Nylons
  • Oxazines
  • nile red
  • diacetylfluorescein