Loading misalignment and tapering of nanowires are usually unavoidable factors in compression and tensile mechanical property testing of nanowires. Herein, we report quantitative finite element analyses and experimental measurements on how these two factors affect the measured compression and tensile mechanical properties if they are not included in the data analysis. The results obtained show that ignoring these two factors leads to different degrees of underestimation of the critical load, Young's modulus and tensile fracture strength.