Normal mast cell numbers in the tissues of AhR-deficient mice

Exp Dermatol. 2016 Jan;25(1):62-3. doi: 10.1111/exd.12864. Epub 2015 Nov 23.

Abstract

The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.

Keywords: aryl hydrocarbon receptor; mast cells; γδ T cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Cell Lineage
  • Female
  • Flow Cytometry
  • Homeostasis
  • Immune System
  • Lymph Nodes / pathology
  • Mast Cells / cytology*
  • Mast Cells / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mucous Membrane / metabolism
  • Peritoneum / metabolism
  • Phenotype
  • Receptors, Aryl Hydrocarbon / genetics*
  • Receptors, Aryl Hydrocarbon / metabolism*
  • Skin / metabolism

Substances

  • Ahr protein, mouse
  • Basic Helix-Loop-Helix Transcription Factors
  • Receptors, Aryl Hydrocarbon