Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
Keywords: ADP ribosylation; Pseudomonas Exotoxin A; Pseudomonas aeruginosa; cytotoxic pathways; pathoadaptation; virulence factor.