p21 upregulation in hair follicle stem cells is associated with telogen retention in aged mice

Exp Dermatol. 2016 Jan;25(1):76-8. doi: 10.1111/exd.12862. Epub 2015 Nov 22.

Authors

A-Ri Cho^{1

2}, Jin Yong Kim^{1

2

3}, Semchin Munkhbayer^{1

2}, Chang-Yup Shin^{1

2}, Ohsang Kwon^{1

2

3}

Affiliations

¹ Institute of Human-Environment Interface Biology, Biomedical Research Center, Seoul National University, Seoul, Korea.
² Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
³ Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

PMID: 26439682
DOI: 10.1111/exd.12862

No abstract available

Keywords: Runx1; hair follicle stem cell; p15; p21; telogen retention.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD34 / metabolism
Cellular Senescence
Core Binding Factor Alpha 2 Subunit / metabolism
Cyclin-Dependent Kinase Inhibitor p15 / metabolism
Cyclin-Dependent Kinase Inhibitor p21 / metabolism*
Epithelial Cells / cytology
Epithelial Cells / immunology
Hair
Hair Follicle / cytology*
Immunohistochemistry
Keratinocytes / cytology
Mice
Microscopy, Confocal
Microscopy, Fluorescence
Stem Cells / metabolism*
Transcriptional Activation
beta-Galactosidase / metabolism

Substances

Antigens, CD34
Cdkn1a protein, mouse
Core Binding Factor Alpha 2 Subunit
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p21
Runx1 protein, mouse
beta-Galactosidase