Biofilm recruitment of Vibrio cholerae by matrix proteolysis

Marylise Duperthuy; Bernt Eric Uhlin; Sun Nyunt Wai

doi:10.1016/j.tim.2015.09.004

Biofilm recruitment of Vibrio cholerae by matrix proteolysis

Trends Microbiol. 2015 Nov;23(11):667-668. doi: 10.1016/j.tim.2015.09.004. Epub 2015 Oct 1.

Authors

Marylise Duperthuy¹, Bernt Eric Uhlin¹, Sun Nyunt Wai²

Affiliations

¹ Department of Molecular Biology and The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-90187 Umeå, Sweden.
² Department of Molecular Biology and The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-90187 Umeå, Sweden. Electronic address: sun.nyunt.wai@umu.se.

PMID: 26439292
DOI: 10.1016/j.tim.2015.09.004

Abstract

The appearance of bacterial biofilms involves secretion of polysaccharides and proteins that form an extracellular matrix embedding the bacteria. Proteases have also been observed, but their role has remained unclear. Smith and co-workers have now found that proteolysis can contribute to further recruitment of bacteria to Vibrio cholerae biofilms.

MeSH terms

Bacterial Adhesion / physiology
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Bacterial Secretion Systems
Biofilms / growth & development*
Extracellular Matrix Proteins / metabolism
Peptide Hydrolases / genetics
Peptide Hydrolases / metabolism
Peptide Hydrolases / physiology*
Polysaccharides, Bacterial / biosynthesis
Polysaccharides, Bacterial / metabolism
Proteolysis
Vibrio cholerae / enzymology
Vibrio cholerae / genetics
Vibrio cholerae / metabolism
Vibrio cholerae / physiology*

Substances

Bacterial Proteins
Bacterial Secretion Systems
Extracellular Matrix Proteins
Polysaccharides, Bacterial
Peptide Hydrolases