Metastasized pancreatic neuroendocrine tumor in a teenage girl: a case report

J Med Case Rep. 2015 Oct 5:9:230. doi: 10.1186/s13256-015-0708-3.

Abstract

Introduction: Metastasized pancreatic neuroendocrine tumors are extremely rare malignancies, especially in children. Therefore, therapeutic options are limited, and few standardized therapy regimens exist.

Case presentation: We report a case of a 14-year-old white girl. In 2011 she was diagnosed with a metastasized, well-differentiated pancreatic neuroendocrine tumor with expression of synaptophysin and chromogranin A. We describe her clinical course with special attention to her individual therapeutic regimens while bringing together several disciplines of medicine.

Conclusions: In patients such as ours, surgical intervention may be the only therapy that will lead to long-term survival.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology*
  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols
  • Chromogranin A / metabolism*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy
  • Neuroendocrine Tumors / diagnosis*
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / therapy
  • Octreotide / administration & dosage
  • Octreotide / analogs & derivatives
  • Organometallic Compounds / administration & dosage
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy
  • Pancreaticoduodenectomy
  • Positron-Emission Tomography
  • Radiopharmaceuticals / administration & dosage
  • Splenomegaly / etiology
  • Synaptophysin / metabolism*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Chromogranin A
  • Ga(III)-DOTATOC
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Synaptophysin
  • Octreotide