A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA

Yao Wang; Qiang Zhao; Yiyang Luo; Zejun Xu; He Zhang; Sheng Yang; Yen Wei; Xinru Jia

doi:10.1039/c5cc05643h

A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA

Chem Commun (Camb). 2015 Dec 7;51(94):16786-9. doi: 10.1039/c5cc05643h.

Authors

Yao Wang¹, Qiang Zhao², Yiyang Luo¹, Zejun Xu¹, He Zhang³, Sheng Yang³, Yen Wei⁴, Xinru Jia¹

Affiliations

¹ Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China.
² Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Peking University, Beijing 100871, P. R. China.
³ Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China. ysdentist@hotmail.com.
⁴ Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.

PMID: 26436149
DOI: 10.1039/c5cc05643h

Abstract

A robust biodegradable hydrogel is constructed from two components containing G4.0 PAMAM and DOPA, which displays excellent interconnected porous 3D networks, higher mechanical strength, low and stable swelling and good biocompatibility. A mouse CSD model in vivo evidences that moderate bone-like tissue and extensive bony tissue are observed when the hydrogel is implanted.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dendrimers / chemistry*
Dihydroxyphenylalanine / chemistry*
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Mechanical Phenomena
Mice
Porosity

Substances

Dendrimers
PAMAM Starburst
Hydrogel, Polyethylene Glycol Dimethacrylate
Dihydroxyphenylalanine