Right hippocampus size is negatively correlated with leptin serum levels in bipolar disorder

Psychiatry Res. 2015 Dec 15;230(2):719-21. doi: 10.1016/j.psychres.2015.09.040. Epub 2015 Sep 28.

Abstract

Obesity is more frequent in bipolar disorder. Adipokines are associated with depression and obesity via the inflammatory process. Twenty-six DSM-IV patients with BD and 39 controls were enrolled to assess the relationship between serum leptin and adiponectin with hippocampal volumes. Among patients, there was a significant negative correlation between right hippocampal volume and serum leptin levels. This result sum for the hypothesis of a pro-inflammatory state associated with BD and the prevalent co-morbid obesity.

Keywords: Adipokines; Bipolar Disorder; Hippocampal volume.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood
  • Adiponectin / blood
  • Adult
  • Biomarkers / blood
  • Bipolar Disorder / blood*
  • Bipolar Disorder / diagnosis*
  • Female
  • Hippocampus / metabolism*
  • Hippocampus / pathology*
  • Humans
  • Leptin / blood*
  • Male
  • Middle Aged
  • Organ Size
  • Pilot Projects

Substances

  • ADIPOQ protein, human
  • Adipokines
  • Adiponectin
  • Biomarkers
  • Leptin