Antioxidant and Anticholinesterase Activities of Essential Oils of Cinnamomum griffithii and C. macrocarpum

Nat Prod Commun. 2015 Aug;10(8):1465-8.

Abstract

The essential oils of Cinnamomum griffithii and C. macrocarpum were analyzed by GC and GC-MS and evaluated for their antioxidant and anticholinesterase activities. The essential oils of leaf and bark of C. grffithii were characterized by the presence of 30 components, with methyl eugenol (38.5-43.8%) as the major component. A total of 11 components were characterized in.the leaf and bark of C. macrocarpum essential oil with the most abundant component was safrole (54.5-59.5%). The bark oil of C. griffithii demonstrated significant activity on DPPH (IC50 73.4 microg/mL) and a high phenolic content (192.0%), while the leaf oil inhibited oxidation of β-carotene/linoleic acid with an inhibition value of 65.5 μg/mL. Acetylcholinesterase and butyrylcholinesterase inhibition were assessed and the results showed that C. macrocarpun bark oil exhibited significant activity with inhibition values of 55.8% and 66.1%, respectively at a concentration of 1 mg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / analysis
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / isolation & purification
  • Cinnamomum / chemistry*
  • Gas Chromatography-Mass Spectrometry
  • Oils, Volatile / chemistry*
  • Oils, Volatile / isolation & purification
  • Plant Oils / chemistry*
  • Plant Oils / isolation & purification

Substances

  • Antioxidants
  • Cholinesterase Inhibitors
  • Oils, Volatile
  • Plant Oils
  • Acetylcholinesterase