The aim of the conducted research was to identify and explain the differences in basic non-standard situational efficiency indicators between winning and defeated European senior basketball teams. Discriminant analysis and Mann-Whitney U-test were used with the purpose of investigating the differences between winning and defeated teams in the domain of basic non-standard situational variables. The grouping variable distinguished 24 defeated teams from 24 winning teams participating in 2009/2010 season of Euroleague Top 16. The research clearly reveals the differences between the winning and defeated European senior basketball teams in the domain of non-standard situational variables of position and transition offense and defense. Eight situational efficiency indicators were used which include the overall number of successful and unsuccessful position and transition defenses and offenses. Based on the results obtained by parametric and non-parametric methods, it has been noticed that successful position defense is crucial for winning, and unsuccessful position offense is an indicator of defeat prediction. Therefore, practical aims in situational training must involve balanced development of relevant abilities and skills which determine successful simultaneous performance of multiple tasks in all the phases of game flow. Such process of sport preparation improves the overall actual quality of players and whole team performance. In conclusion, it is important to emphasize that the process of improving position and transition defense stimulates the development of position and transition offense, and vice versa.