Roles of Lipoproteins and Apolipoproteins in Particle Formation of Hepatitis C Virus

Takasuke Fukuhara; Chikako Ono; Francesc Puig-Basagoiti; Yoshiharu Matsuura

doi:10.1016/j.tim.2015.07.007

Roles of Lipoproteins and Apolipoproteins in Particle Formation of Hepatitis C Virus

Trends Microbiol. 2015 Oct;23(10):618-629. doi: 10.1016/j.tim.2015.07.007.

Authors

Takasuke Fukuhara¹, Chikako Ono¹, Francesc Puig-Basagoiti¹, Yoshiharu Matsuura²

Affiliations

¹ Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
² Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. Electronic address: matsuura@biken.osaka-u.ac.jp.

PMID: 26433694
DOI: 10.1016/j.tim.2015.07.007

Abstract

More than 160 million people worldwide are infected with hepatitis C virus (HCV), and cirrhosis and hepatocellular carcinoma induced by HCV infection are life-threatening diseases. HCV takes advantage of many aspects of lipid metabolism for an efficient propagation in hepatocytes. Due to the morphological and physiological similarities of HCV particles to lipoproteins, lipid-associated HCV particles are named lipoviroparticles. Recent analyses have revealed that exchangeable apolipoproteins directly interact with the viral membrane to generate infectious HCV particles. In this review, we summarize the roles of lipid metabolism in the life cycle of HCV.

Keywords: amphipathic α-helices; exchangeable apolipoproteins; hepato-tropism.; lipoprotein.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apolipoproteins / metabolism*
Hepacivirus / chemistry
Hepacivirus / metabolism*
Lipoproteins / metabolism*
Virion / metabolism
Virus Assembly

Substances

Apolipoproteins
Lipoproteins