Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation

Harry Sokol; Tatiana Galperine; Nathalie Kapel; Pierre Bourlioux; Philippe Seksik; Frederic Barbut; Julien Scanzi; François Chast; Rui Batista; Francisca Joly; Anne-Christine Joly; Anne Collignon; Benoit Guery; Laurent Beaugerie; French Group of Faecal microbiota Transplantation (FGFT)

doi:10.1016/j.dld.2015.08.017

Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation

Dig Liver Dis. 2016 Mar;48(3):242-7. doi: 10.1016/j.dld.2015.08.017. Epub 2015 Sep 7.

Authors

Collaborators

French Group of Faecal microbiota Transplantation (FGFT):
Laurent Alric, Jean-Paul Aucouturier, Aurelien Amiot, Frederic Barbut, Rui Batista, Laurent Beaugerie, Pascale Bemer, Robert Benamouzig, Nicolas Benech, Claire Billioud, Gille Boschetti, Pierre Bourlioux, Nour Boubaddi, Guillaume Bouguen, Arnaud Bourreille, Franck Carbonnel, Elodie Cesbron-Metivier, François Chast, Benoit Coffin, Anne Collignon, Michael Collins, Benjamin Davido, Thierry Davion, Aurelilen Dinh, Henri Duboc, Philippe Ducrotte, Thibaut Fraisse, Bertrand Gachot, Tatiana Galperine, Benoit Guery, Marielle Guillet, B Heyman, Anne-Christine Joly, Francisca Joly, Nathalie Kapel, Elodie Metivier, Frederic Mille, Alexis Mosca, Biba Nebbad, Gabriel Perlemuter, Thierry Piche, Jean-Marie Reimund, Matthieu Revest, Jean-Marc Sabate, Julien Scanzi, Philippe Seksik, Iradj Sobhani, Harry Sokol, Stephane Schneider, Caroline Trang, Stephanie Viennot, Maurice Viala, Cosmin Voican, Frank Zerbib

Affiliations

¹ Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France. Electronic address: harry.sokol@aphp.fr.
² Infectious Diseases Department, Huriez Hospital, CHRU Lille, Lille 2 University, France.
³ Functional Coprology Laboratory, Pitié Salpêtrière Hospital - Charles Foix, Paris Descartes University, AP-HP and EA 4065, Paris, France.
⁴ Pharmacy Academy, Paris, France; Microbiology Department, Pharmacy Faculty, Paris-Sud University, France.
⁵ Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France.
⁶ C. difficile National Reference Laboratory, Saint-Antoine Hospital, AP-HP et UPMC Paris 06 University, GRC N°2 EPIDIFF, Paris, France.
⁷ Gastro-enterology Department, Hôpital Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
⁸ Pharmacy Academy, Paris, France; Clinical Pharmacy Department, Paris University Hospital, AP-HP, Paris France.
⁹ Gastro-enterology Department, Beaujon Hospital, AP-HP, and Paris 7 University, Clichy, France.
¹⁰ Pharmacy Department, Preparation Unit, Saint-Antoine Hospital, AP-HP, Paris, France.
¹¹ EA 4043, Pharmacy Faculty, Paris Sud University, France.

PMID: 26433619
DOI: 10.1016/j.dld.2015.08.017

Abstract

Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium difficile infection and its use in this indication is recommended in the most recent European and North American guidelines. In this context, faecal microbiota transplantation is beginning to be performed in France in clinical practice, while the rules governing this procedure have been defined in France only for clinical trials. To unify, secure, and evaluate practice in this field in France, the French Group of Faecal microbiota Transplantation (FGFT) was created in October 2014 with the support of the French National Society of Gastroenterology, the French Infectious Disease Society, and the National Academy of Pharmacy. We present here the deliberations of this group regarding the use of faecal microbiota transplantation for recurrent Clostridium difficile infection. The issues addressed are the indications, therapeutic sequence, delivery procedures, donor selection, methods and conditions of specimen preparation, and traceability.

Keywords: Clostridium difficile; Faecal microbiota transplantation; Recommendations.

Publication types

Practice Guideline
Research Support, Non-U.S. Gov't

MeSH terms

Clostridioides difficile*
Clostridium Infections / therapy
Donor Selection
Enterocolitis, Pseudomembranous / therapy*
Fecal Microbiota Transplantation / methods*
France
Gastroenterology
Humans
Patient Selection
Recurrence