Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Bioresour Technol. 2015 Dec:198:571-6. doi: 10.1016/j.biortech.2015.09.075. Epub 2015 Sep 26.

Abstract

This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid>oxalic acid>furfural>5-HMF>Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

Keywords: Butanol fermentation; Dose response; Probit analysis; Toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomass
  • Butanols / metabolism*
  • Clostridium acetobutylicum / drug effects
  • Clostridium acetobutylicum / growth & development
  • Clostridium acetobutylicum / metabolism*
  • Dose-Response Relationship, Drug
  • Fermentation
  • Formates / metabolism
  • Formates / pharmacology
  • Furaldehyde / metabolism
  • Furaldehyde / pharmacology
  • Hydrogen / metabolism
  • Hydrolysis
  • Industrial Microbiology / methods*
  • Oxalic Acid / metabolism
  • Oxalic Acid / pharmacology
  • Sulfates / pharmacology

Substances

  • Butanols
  • Formates
  • Sulfates
  • formic acid
  • sodium sulfate
  • Hydrogen
  • Oxalic Acid
  • Furaldehyde