The Hruska postulate of Crohn's disease

Med Hypotheses. 2015 Dec;85(6):878-81. doi: 10.1016/j.mehy.2015.09.019. Epub 2015 Sep 30.

Abstract

Crohn's disease is due to the loss of immunological tolerance within the gastrointestinal tract to the antigenic array of Mycobacterium avium subspecies paratuberculosis (MAP) and closely related polymorphic variants. The loss of immune tolerance results in an effector cytokine responsive upon re-exposure to MAP. For immune tolerance to MAP to be induced, infection must occur when acquired immunity is markedly underdeveloped.

MeSH terms

  • Adaptive Immunity
  • Animals
  • Autoimmunity
  • Breast Feeding
  • Colitis / microbiology
  • Crohn Disease / diagnosis
  • Crohn Disease / microbiology*
  • Crohn Disease / physiopathology*
  • Cytokines / metabolism
  • Dairying
  • Gastrointestinal Tract / immunology
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Immune System
  • Immune Tolerance
  • Milk / microbiology
  • Mycobacterium avium subsp. paratuberculosis*
  • Protein Binding

Substances

  • Cytokines