Role of linezolid therapeutic drug monitoring in the treatment of MRSA tracheo-pulmonary infection in a 10-month-old infant

J Chemother. 2016 Dec;28(6):517-519. doi: 10.1179/1973947815Y.0000000074. Epub 2016 Jul 25.

Abstract

The paper reports on the use of therapeutic drug monitoring for linezolid in the decision-making process to continue or not its administration in an infant. Linezolid is effective against methicillin-resistant Staphylococcus aureus but is off-label in pediatrics. The use of therapeutic drug monitoring, as in our case, allows an informed decision on administration of the drug (in this case on withdrawal) increasing patients safety.

Keywords: Linezolid; Paediatrics; Therapeutic drug monitoring.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Monitoring*
  • Humans
  • Infant
  • Linezolid / blood
  • Linezolid / therapeutic use*
  • Lung Diseases / blood
  • Lung Diseases / drug therapy*
  • Male
  • Methicillin-Resistant Staphylococcus aureus*
  • Staphylococcal Infections / blood
  • Staphylococcal Infections / drug therapy*
  • Tracheal Diseases / blood
  • Tracheal Diseases / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Linezolid