Fat Chance for Neural Stem Cells in Alzheimer's Disease

Geraldine Gontier; Karin Lin; Saul A Villeda

doi:10.1016/j.stem.2015.09.006

Fat Chance for Neural Stem Cells in Alzheimer's Disease

Cell Stem Cell. 2015 Oct 1;17(4):373-4. doi: 10.1016/j.stem.2015.09.006.

Authors

Geraldine Gontier¹, Karin Lin², Saul A Villeda³

Affiliations

¹ Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.
² Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
³ Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: saul.villeda@ucsf.edu.

PMID: 26431177
DOI: 10.1016/j.stem.2015.09.006

Abstract

Identifying factors driving neural stem cell dysfunction in age-related neurodegenerative diseases remains critical for the development of potential regenerative therapies. Now in Cell Stem Cell,Hamilton et al. (2015) find that lipid accumulation observed during early stages of Alzheimer's disease impairs neural stem cell activity in the adult brain.

Publication types

Comment

MeSH terms

Animals
Lipid Metabolism*
Neural Stem Cells*
Prosencephalon / metabolism*