One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction

Jiaming Tang; Bingqing Xu; Xi Mao; Hongyan Yang; Xiaoxia Wang; Xin Lv

doi:10.1021/acs.joc.5b01745

One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction

J Org Chem. 2015 Nov 6;80(21):11108-14. doi: 10.1021/acs.joc.5b01745. Epub 2015 Oct 9.

Authors

Jiaming Tang¹, Bingqing Xu¹, Xi Mao¹, Hongyan Yang¹, Xiaoxia Wang¹, Xin Lv¹

Affiliation

¹ Department of Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University , Jinhua 321004, People's Republic of China.

PMID: 26430717
DOI: 10.1021/acs.joc.5b01745

Abstract

A novel and efficient synthesis of pyrrolo[3,2,1-kl]phenothiazines has been developed through a Cu(I)-catalyzed tandem C-S coupling/double cyclization process. Using 2-alkynyl-6-iodoanilines and o-bromobenzenethiols as the starting materials, a wide range of pyrrolo[3,2,1-kl]phenothiazine derivatives were facilely and efficiently generated in one pot under Cu(I) catalysis.

Publication types

Research Support, Non-U.S. Gov't