Timing of Gonadectomy in Patients with Complete Androgen Insensitivity Syndrome-Current Recommendations and Future Directions

Vrunda Patel; Rachel Kastl Casey; Veronica Gomez-Lobo

doi:10.1016/j.jpag.2015.03.011

Timing of Gonadectomy in Patients with Complete Androgen Insensitivity Syndrome-Current Recommendations and Future Directions

J Pediatr Adolesc Gynecol. 2016 Aug;29(4):320-5. doi: 10.1016/j.jpag.2015.03.011. Epub 2015 Mar 28.

Authors

Vrunda Patel¹, Rachel Kastl Casey², Veronica Gomez-Lobo²

Affiliations

¹ Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware. Electronic address: Vrunda.Patel@medstar.net.
² Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center/Children's National Medical Center, Washington, DC.

PMID: 26428189
DOI: 10.1016/j.jpag.2015.03.011

Abstract

This review highlights the controversy regarding timing of gonadectomy in patients with complete androgen insensitivity syndrome (CAIS). We will review the published literature regarding frequency of gonadal malignancy and summarize historical findings. Recent research suggests that gonadectomy may be deferred until adulthood due to the low risk of malignancy. An algorithm is also provided to help guide clinicians in management of patients with complete androgen insensitivity syndrome who have deferred gonadectomy.

Keywords: Complete androgen insensitivity syndrome; Gonadectomy; Testicular feminization syndrome.

Publication types

Review

MeSH terms

Algorithms
Androgen-Insensitivity Syndrome / surgery*
Castration / methods*
Clinical Decision-Making / methods*
Female
Humans
Male
Risk Factors
Time-to-Treatment*