Non-High-Density Lipoprotein Cholesterol in Children with Diabetes: Proposed Treatment Recommendations Based on Glycemic Control, Body Mass Index, Age, Sex, and Generally Accepted Cut Points

K Otfried Schwab; Jürgen Doerfer; Andreas Hungele; Nicole Scheuing; Andreas Krebs; Axel Dost; Tilman R Rohrer; Sabine Hofer; Reinhard W Holl

doi:10.1016/j.jpeds.2015.09.006

Non-High-Density Lipoprotein Cholesterol in Children with Diabetes: Proposed Treatment Recommendations Based on Glycemic Control, Body Mass Index, Age, Sex, and Generally Accepted Cut Points

J Pediatr. 2015 Dec;167(6):1436-9. doi: 10.1016/j.jpeds.2015.09.006. Epub 2015 Oct 1.

Authors

K Otfried Schwab¹, Jürgen Doerfer², Andreas Hungele³, Nicole Scheuing³, Andreas Krebs², Axel Dost⁴, Tilman R Rohrer⁵, Sabine Hofer⁶, Reinhard W Holl³

Affiliations

¹ Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany. Electronic address: karl.otfried.schwab@uniklinik-freiburg.de.
² Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.
³ Institute of Epidemiology and Medical Biometry, German Center for Diabetes Research (DHZ), University of Ulm, Ulm, Germany.
⁴ Department of Pediatrics and Adolescent Medicine, University of Jena, Jena, Germany.
⁵ Division of Pediatric Endocrinology, Department of General Pediatrics and Neonatology, Saarland University Medical Center, Homburg/Saar, Germany.
⁶ Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.

PMID: 26427965
DOI: 10.1016/j.jpeds.2015.09.006

Abstract

Percentile-based non-high-density lipoprotein cholesterol levels were analyzed by glycemic control, weight, age, and sex of children with type 1 diabetes (n = 26,358). Ten percent of all children and 25% of overweight adolescent girls require both immediate lipid-lowering medication and lifestyle changes to achieve non-high-density lipoprotein cholesterol levels <120 mg/dL and cardiovascular risk reduction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Blood Glucose / metabolism*
Body Mass Index*
Cardiovascular Diseases / blood*
Cardiovascular Diseases / etiology
Cardiovascular Diseases / prevention & control
Child
Cholesterol, HDL / blood*
Diabetes Mellitus, Type 1 / blood*
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 1 / drug therapy
Female
Glycated Hemoglobin / metabolism
Humans
Hypoglycemic Agents / therapeutic use*
Male
Practice Guidelines as Topic*
Risk Factors

Substances

Blood Glucose
Cholesterol, HDL
Glycated Hemoglobin A
Hypoglycemic Agents
hemoglobin A1c protein, human