Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Andras Bikov; James H Hull; Laszlo Kunos

doi:10.1016/j.smrv.2015.07.005

Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Sleep Med Rev. 2016 Jun:27:1-8. doi: 10.1016/j.smrv.2015.07.005. Epub 2015 Aug 5.

Authors

Andras Bikov¹, James H Hull², Laszlo Kunos³

Affiliations

¹ Department of Pulmonology, Semmelweis University, Budapest, Hungary. Electronic address: andras.bikov@gmail.com.
² Department of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
³ Department of Pulmonology, Semmelweis University, Budapest, Hungary.

PMID: 26426372
DOI: 10.1016/j.smrv.2015.07.005

Abstract

Accelerated airway inflammation may play a crucial role in the pathophysiology of obstructive sleep apnoea (OSA); however this phenomenon has been investigated only in a limited number of studies. The analysis of exhaled breath represents a promising, non-invasive tool to evaluate airway inflammation in this context. The knowledge on exhaled biomarkers in OSA has been growing with an emerging number of methodological studies which help to interpret exhaled breath data. This article not only summarises the results of studies on exhaled breath condensate (EBC) biomarkers, exhaled volatile compounds and exhaled monoxides in OSA, but also aims to critically review methodological limitations and provide some guideline for further research.

Keywords: Breath test; Exhaled breath condensate; Exhaled nitric oxide; Obstructive sleep apnoea.

Publication types

Review

MeSH terms

Biomarkers / analysis
Breath Tests / methods*
Carbon Monoxide / analysis
Humans
Inflammation / etiology
Nitric Oxide / analysis
Sleep Apnea, Obstructive / physiopathology*

Substances

Biomarkers
Nitric Oxide
Carbon Monoxide