Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo

J Contemp Dent Pract. 2015 Aug 1;16(8):674-8. doi: 10.5005/jp-journals-10024-1739.

Abstract

Aim: To evaluate the effectiveness of five different mouthwashes through measurement of the plaque index.

Materials and methods: Fifty subjects took part in this blind study, randomized into blocks of five groups according to the active ingredient of the mouthwash: CHX group (0.12% chlorhexidine gluconate), essential oils (EO) group, cetylpyridinium chloride (CPC) group, Tri group (triclosan) and Hamamelis virginiana (HV) group. All subjects were evaluated for a reduction in the bacterial plaque index at 7, 14 and 21 days.

Results: There was a significant reduction in the mean plaque index during the period of evaluation (p < 0.01), and the reduction during the period of evaluation was different between mouthwashes (p < 0.01). The reduction in the plaque index at the end of 21 days was, in decreasing order, CHX > EO > CPC > Tri > HV.

Conclusion: The reduction in the plaque index during the period of evaluation was different between the types of mouth-wash. The mouthwash containing the active ingredient chlorhexidine was the most effective, followed by the essential oil, cetylpyridinium chloride, triclosan and H. virginiana.

Keywords: Antimicrobial activity; Mouthwash; Tooth biofilm.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Anti-Infective Agents, Local / administration & dosage*
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Cetylpyridinium / administration & dosage
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / analogs & derivatives
  • Dental Plaque / microbiology
  • Dental Plaque / prevention & control*
  • Double-Blind Method
  • Female
  • Hamamelis / chemistry
  • Humans
  • Male
  • Mouthwashes / administration & dosage*
  • Oils, Volatile / administration & dosage
  • Triclosan / administration & dosage

Substances

  • Anti-Infective Agents, Local
  • Mouthwashes
  • Oils, Volatile
  • Triclosan
  • Cetylpyridinium
  • chlorhexidine gluconate
  • Chlorhexidine