Epigenetic control of podocyte differentiation: a new target of the renin-angiotensin system in kidney disease

Kidney Int. 2015 Oct;88(4):668-70. doi: 10.1038/ki.2015.224.

Abstract

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

Publication types

  • Comment

MeSH terms

  • Albuminuria / prevention & control*
  • Angiotensin II Type 1 Receptor Blockers / pharmacology*
  • Animals
  • Benzimidazoles / pharmacology*
  • Biphenyl Compounds / pharmacology*
  • Epigenesis, Genetic / drug effects*
  • Kruppel-Like Transcription Factors / metabolism*
  • Male
  • Podocytes / drug effects*
  • Renal Insufficiency, Chronic / drug therapy*
  • Renin-Angiotensin System / drug effects*
  • Tetrazoles / pharmacology*

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Benzimidazoles
  • Biphenyl Compounds
  • Kruppel-Like Transcription Factors
  • Tetrazoles