Abstract
Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.
MeSH terms
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Albuminuria / prevention & control*
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Angiotensin II Type 1 Receptor Blockers / pharmacology*
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Animals
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Benzimidazoles / pharmacology*
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Biphenyl Compounds / pharmacology*
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Epigenesis, Genetic / drug effects*
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Kruppel-Like Transcription Factors / metabolism*
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Male
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Podocytes / drug effects*
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Renal Insufficiency, Chronic / drug therapy*
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Renin-Angiotensin System / drug effects*
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Tetrazoles / pharmacology*
Substances
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Angiotensin II Type 1 Receptor Blockers
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Benzimidazoles
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Biphenyl Compounds
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Kruppel-Like Transcription Factors
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Tetrazoles