Flow cytometry in immunoglobulin light chain amyloidosis: Short review

Jana Filipova; Lucie Rihova; Pavla Vsianska; Zuzana Kufova; Elena Kryukova; Fedor Kryukov; Roman Hajek

doi:10.1016/j.leukres.2015.07.002

Flow cytometry in immunoglobulin light chain amyloidosis: Short review

Leuk Res. 2015 Jul 13:S0145-2126(15)30345-3. doi: 10.1016/j.leukres.2015.07.002. Online ahead of print.

Authors

Jana Filipova¹, Lucie Rihova², Pavla Vsianska², Zuzana Kufova³, Elena Kryukova³, Fedor Kryukov³, Roman Hajek⁴

Affiliations

¹ Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic; Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Electronic address: jafilipo@seznam.cz.
² Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic; Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
³ Department of Haematooncology, University Hospital Ostrava and Faculty of Medicine OU, Ostrava, Czech Republic.
⁴ Department of Haematooncology, University Hospital Ostrava and Faculty of Medicine OU, Ostrava, Czech Republic. Electronic address: roman.hajek@fno.cz.

PMID: 26422558
DOI: 10.1016/j.leukres.2015.07.002

Abstract

Flow cytometry (FCM) has found its application in clinical diagnosis and evaluation of monoclonal gammopathies (MG). Although, research has been mainly focused on multiple myeloma (MM), nowadays FCM becomes to be potential tool in the field of AL amyloidosis. Clonal plasma cells identification and specific phenotype profile detection is important for diagnosis, monitoring and prognosis of AL amyloidosis. Therefore, FCM could be a perspective method for study not only MM but also AL amyloidosis. This review provides an overview and possibilities of FCM application in AL amyloidosis.

Keywords: AL amyloidosis; Flow cytometry; Monoclonal gammopathy; Plasma cell.

Publication types

Review