A total of 783 women aged 41-50 were examined in the Out-Patient Clinic in Novi Sad in the period from 1975-1987 due to prolonged uterine bleeding and the explorative curettage was performed in 12 (7%) of them. The most frequent histopathologic results were as follows: hiperplasio glandularis endometrii simplex in 25 (22.3%), hyperplasio glandularis cystica endometrii in 17 (15.7%), hyperplasio adenomatoides endometrii in 12 (10.7%), endometritis chronica in 18 (16%), phasis secretionis endometrii in 7 (6.2%), phasis proliferationis endometrii in 3 (2.6%), endometritis acuta non specifica post graviditates in 5 (4.4%), residua decidualis necrotica cum charione in 8 (7.1%), mola hydatidosa in 1 (0.9%), polypus endometrialis in 3 (2.6%), and adenocarcinoma endometrialis in 3 (2.6%). Uterine bleeding is a very frequent appearance in women's premenopausal period and apart from gynecologic survey it also necessitates the application of diagnostic methods and interventions such as the curretman's histologic investigation intended for the detection of pathologic changes in the endometrium.