Mesostructured TiO2 Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release

Small. 2015 Nov 25;11(44):5907-11. doi: 10.1002/smll.201501835. Epub 2015 Sep 29.

Abstract

A multistimuli-responsive drug carrier is designed and successfully synthesized by self-assembly of thiol-modified periodic mesoporous organosilica (PMO) nanoparticles, coated gold nanoparticles (AuNPs), and mesostructured titanium dioxide (TiO2). Dye-loaded PMO-Au@TiO2 nanotablets are shown to respond to environmental changes (pH, temperature, and light) to achieve controlled release.

Keywords: drug delivery; mesoporous materials; organic-inorganic hybrid materials; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Liberation*
  • Erythrocytes / drug effects
  • Hemolysis / drug effects
  • Humans
  • Methylene Blue / pharmacology
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Nitrogen / chemistry
  • Organosilicon Compounds / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*
  • Temperature
  • Titanium / chemistry*

Substances

  • Organosilicon Compounds
  • titanium dioxide
  • Silicon Dioxide
  • Titanium
  • Nitrogen
  • Methylene Blue