Observation of sound-induced corneal vibrational modes by optical coherence tomography

B Imran Akca; Ernest W Chang; Sabine Kling; Antoine Ramier; Giuliano Scarcelli; Susana Marcos; Seok H Yun

doi:10.1364/BOE.6.003313

Observation of sound-induced corneal vibrational modes by optical coherence tomography

Biomed Opt Express. 2015 Aug 11;6(9):3313-9. doi: 10.1364/BOE.6.003313. eCollection 2015 Sep 1.

Authors

B Imran Akca¹, Ernest W Chang¹, Sabine Kling², Antoine Ramier³, Giuliano Scarcelli⁴, Susana Marcos⁵, Seok H Yun¹

Affiliations

¹ Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA.
² Instituto de Óptica, Consejo Superior de Investigaciónes Cientificas, Madrid, Spain.
³ Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA ; The Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
⁴ Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA ; Department of Bioengineering, 2217 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
⁵ Instituto de Óptica, Consejo Superior de Investigaciónes Cientificas, Madrid, Spain ; susana@io.cfmac.csic.es.

Abstract

The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was ~8 µm at a sound pressure level of 100 dB (2 Pa). Vibrography allows the visualization of the radially symmetric profiles of the resonance modes. A dynamic finite-element analysis supports our observation.

Keywords: (100.3010) Image reconstruction techniques; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography.

Abstract

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