Anticancer Platelet-Mimicking Nanovehicles

Adv Mater. 2015 Nov 25;27(44):7043-50. doi: 10.1002/adma.201503323. Epub 2015 Sep 29.

Abstract

A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.

Keywords: biomimetic; drug delivery; nanomedicine; nanoparticle; platelet.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Biomimetic Materials / chemistry*
  • Blood Platelets / cytology*
  • Cell Line, Tumor
  • Cell Membrane / chemistry
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers / chemistry*
  • Humans
  • Intracellular Space / metabolism
  • Mice
  • Nanomedicine / methods*
  • Nanostructures / chemistry*
  • TNF-Related Apoptosis-Inducing Ligand / chemistry
  • TNF-Related Apoptosis-Inducing Ligand / metabolism

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • TNF-Related Apoptosis-Inducing Ligand
  • Doxorubicin