MicroRNA in prostate cancer

Clin Chim Acta. 2015 Dec 7;451(Pt B):154-60. doi: 10.1016/j.cca.2015.09.022. Epub 2015 Sep 28.

Abstract

In the United States of America male prostate cancer (PCa) is the most dominant malignancy and the second highest cause of cancer-related mortality risk compared to lung and colon cancers. MicroRNAs (miRNAs) are a class of endogenously expressed small, non-coding, single-stranded RNA which function as regulators of gene expression. They influence various physiological and pathophysiological processes. In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed.

Keywords: Androgen; MicroRNA (miRNA); Post-transcription; Prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle
  • Cell Proliferation
  • Humans
  • Male
  • MicroRNAs / metabolism*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy
  • Receptors, Androgen / metabolism

Substances

  • MicroRNAs
  • Receptors, Androgen