A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena

Chin J Nat Med. 2015 Sep;13(9):699-703. doi: 10.1016/S1875-5364(15)30068-6.

Abstract

A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7, 9-diol-7'-aldehyde (5), kaempferol-3-O-(2″,6″-di-O-p-trans-coumaroyl)-β-glucoside (6), arjunolic acid (7), vanillic acid (8), scoparone (9), and β-sitosterol (10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L(-1), respectively.

Keywords: Anti-inflammation; Melongenolide A; Solanaceae; Solanum melongena; γ-Alkylated-γ-butyrolactone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / isolation & purification
  • Animals
  • Furans / isolation & purification
  • Furans / pharmacology
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Inhibitory Concentration 50
  • Kaempferols / isolation & purification
  • Kaempferols / pharmacology
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry*
  • RAW 264.7 Cells
  • Solanum melongena / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • Furans
  • Kaempferols
  • Lignans
  • Plant Extracts
  • Triterpenes
  • syringaresinol
  • Nitric Oxide
  • arjunolic acid
  • kaempferol
  • 4-Butyrolactone