GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases

Craig I McKenzie; Charles R Mackay; Laurence Macia

doi:10.1016/j.tem.2015.07.009

GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases

Trends Endocrinol Metab. 2015 Oct;26(10):511-512. doi: 10.1016/j.tem.2015.07.009.

Authors

Craig I McKenzie¹, Charles R Mackay², Laurence Macia³

Affiliations

¹ Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
² Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address: charles.mackay@pfizer.com.
³ Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia; School of Medical Sciences, The University of Sydney, NSW 2006, Australia. Electronic address: laurence.macia@monash.edu.

PMID: 26412151
DOI: 10.1016/j.tem.2015.07.009

Abstract

Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of 'Western lifestyle' diseases.

Keywords: Fiber; GPR43; SCFAs; inflammation; metabolism.

Publication types

Review

MeSH terms

Animals
Fatty Acids, Volatile / metabolism*
Humans
Inflammation / metabolism*
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / metabolism*

Substances

Fatty Acids, Volatile
Receptors, G-Protein-Coupled