Liposomal Bupivacaine: A Comparative Study of More Than 1000 Total Joint Arthroplasty Cases

Orthop Clin North Am. 2015 Oct;46(4):469-77. doi: 10.1016/j.ocl.2015.06.003. Epub 2015 Aug 6.

Abstract

Pain after total joint arthroplasty (TJA) can be severe and difficult to control. A single-dose local analgesic delivers bupivacaine in a liposomal time-release platform. In 2248 consecutive patients with hip and knee arthroplasty, half (Pre) were treated using a well-established multimodal analgesia, including periarticular injection (PAI), and half had the PAI substituted for a liposomal bupivacaine injection technique (Post). Pain scores were significantly lower for patients in the Post group for both hip and knee procedures. A large series of patients who had TJA experienced pain relief after the introduction of liposomal bupivacaine as part of an established multimodal protocol.

Keywords: Analgesia; Hip arthroplasty; Knee arthroplasty; Liposomal bupivacaine; Pain control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Anesthetics, Local / administration & dosage*
  • Arthroplasty, Replacement, Finger*
  • Arthroplasty, Replacement, Knee*
  • Bupivacaine / administration & dosage*
  • Delayed-Action Preparations
  • Female
  • Humans
  • Liposomes / administration & dosage
  • Male
  • Middle Aged
  • Pain Measurement
  • Pain, Postoperative / diagnosis
  • Pain, Postoperative / drug therapy*
  • Retrospective Studies

Substances

  • Anesthetics, Local
  • Delayed-Action Preparations
  • Liposomes
  • Bupivacaine