G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.
Keywords: GPCR; dimers; heteromer; model; oligomer; structure.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.