Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

Trends Biochem Sci. 2015 Oct;40(10):548-551. doi: 10.1016/j.tibs.2015.07.007.

Abstract

G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.

Keywords: GPCR; dimers; heteromer; model; oligomer; structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • GTP-Binding Proteins / chemistry*
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Protein Binding
  • Protein Conformation
  • Receptors, G-Protein-Coupled / chemistry*
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins