Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer

J Biotechnol. 2015 Nov 20:214:117-8. doi: 10.1016/j.jbiotec.2015.09.020. Epub 2015 Sep 26.

Abstract

Streptomyces ambofaciens ATCC23877 is a soil bacterium industrially exploited for the production of the macrolide spiramycin which is used in human medicine as an antibacterial and anti-toxoplasmosis chemical. Its genome consists of a 8.3 Mbp linear chromosome and a 89 kb circular plasmid. The complete genome sequence reported here will enable us to investigate Streptomyces genome evolution and to discover new secondary metabolites with potential applications notably in human medicine.

Keywords: Gene clusters; Genome instability; Genome sequence; Streptomyces ambofaciens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Bacterial / genetics
  • Evolution, Molecular
  • Genome, Bacterial / genetics*
  • Plasmids / genetics
  • Soil Microbiology
  • Spiramycin / metabolism*
  • Streptomyces / genetics*
  • Streptomyces / metabolism*

Substances

  • Spiramycin