Drug-Induced Acute Kidney Injury: A Focus on Risk Assessment for Prevention

Sandra L Kane-Gill; Stuart L Goldstein

doi:10.1016/j.ccc.2015.06.005

Drug-Induced Acute Kidney Injury: A Focus on Risk Assessment for Prevention

Crit Care Clin. 2015 Oct;31(4):675-84. doi: 10.1016/j.ccc.2015.06.005.

Authors

Sandra L Kane-Gill¹, Stuart L Goldstein²

Affiliations

¹ Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, 918 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Center for Critical Care Nephology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: SLK54@pitt.edu.
² Center for Acute Care Nephrology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229, USA.

PMID: 26410137
DOI: 10.1016/j.ccc.2015.06.005

Abstract

Drugs are the third to fifth leading cause of acute kidney injury (AKI) in critically ill patients following sepsis and hypotension. Susceptibilities and exposures for development of AKI have been identified, and some are modifiable allowing for the possibility of AKI prevention or mitigation of AKI severity. Using drug therapies for prevention of AKI has been attempted but with little success in human studies, so we must rely on risk-assessment strategies for prevention. The purpose of this article is to review the risk factors, risk-assessment strategies, prevention, and management of drug-induced AKI with emphasis on risk assessment.

Keywords: Acute kidney injury; Drug-induced acute kidney injury; Drug-related side effects and adverse drug reactions; Prevention; Risk assessment; Risk factors.

Publication types

Review

MeSH terms

Acute Kidney Injury / chemically induced*
Acute Kidney Injury / epidemiology
Acute Kidney Injury / prevention & control*
Acute Kidney Injury / therapy
Humans
Risk Assessment
Risk Factors