New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA

J Inorg Biochem. 2015 Dec:153:32-41. doi: 10.1016/j.jinorgbio.2015.08.016. Epub 2015 Aug 29.

Abstract

A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.

Keywords: Corroles; Deoxyribonucleic acid (DNA); Human serum albumin (HSA); Plasmid DNA (pDNA); Platinum(II) complexes; trans-A(2)B corroles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,2'-Dipyridyl / chemical synthesis
  • 2,2'-Dipyridyl / chemistry*
  • Animals
  • Cattle
  • DNA / chemistry*
  • Electrophoresis, Agar Gel
  • Humans
  • Organoplatinum Compounds / chemical synthesis
  • Organoplatinum Compounds / chemistry*
  • Plasmids / chemistry
  • Porphyrins / chemical synthesis
  • Porphyrins / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • Serum Albumin / chemistry*
  • Spectrometry, Fluorescence

Substances

  • Organoplatinum Compounds
  • Porphyrins
  • Serum Albumin
  • 2,2'-Dipyridyl
  • DNA
  • calf thymus DNA