Discovery and functional characterization of cardiovascular long noncoding RNAs

Samir Ounzain; Frédéric Burdet; Mark Ibberson; Thierry Pedrazzini

doi:10.1016/j.yjmcc.2015.09.013

Discovery and functional characterization of cardiovascular long noncoding RNAs

J Mol Cell Cardiol. 2015 Dec;89(Pt A):17-26. doi: 10.1016/j.yjmcc.2015.09.013. Epub 2015 Sep 25.

Authors

Samir Ounzain¹, Frédéric Burdet², Mark Ibberson², Thierry Pedrazzini³

Affiliations

¹ Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland. Electronic address: samir.ounzain@chuv.ch.
² Vital-IT, Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland.
³ Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland. Electronic address: thierry.pedrazzini@chuv.ch.

PMID: 26408097
DOI: 10.1016/j.yjmcc.2015.09.013

Abstract

Recent advances in sequencing and genomic technologies have resulted in the discovery of thousands of previously unannotated long noncoding RNAs (lncRNAs). However, their function in the cardiovascular system remains elusive. Here we review and discuss considerations for cardiovascular lncRNA discovery, annotation and functional characterization. Although we primarily focus on the heart, the proposed pipeline should foster functional and mechanistic exploration of these transcripts in various cardiovascular pathologies. Moreover, these insights could ultimately lead to novel therapeutic approaches targeting lncRNAs for the amelioration of cardiovascular diseases including heart failure.

Keywords: Cardiovascular disease; Discovery; Functional characterization; Genomics; Long noncoding RNA.

Publication types

Review

MeSH terms

Animals
Cardiovascular System / metabolism*
Humans
Molecular Sequence Annotation
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism

Substances

RNA, Long Noncoding