Linezolid-Associated Thrombocytopenia in Children With Renal Impairment

Sara J Jones; Kristen R Nichols; Heather L DeYoung; Elaine G Cox; Chad A Knoderer

doi:10.1093/jpids/piu035

Linezolid-Associated Thrombocytopenia in Children With Renal Impairment

J Pediatric Infect Dis Soc. 2015 Sep;4(3):272-5. doi: 10.1093/jpids/piu035. Epub 2014 May 15.

Authors

Sara J Jones¹, Kristen R Nichols², Heather L DeYoung³, Elaine G Cox³, Chad A Knoderer⁴

Affiliations

¹ Department of Pharmacy, Lutheran Hospital, Fort Wayne, Indiana;
² Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana; Department of Pharmacy, Riley Hospital for Children at Indiana University Health, Indianapolis; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis.
³ Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis.
⁴ Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana;

PMID: 26407433
DOI: 10.1093/jpids/piu035

Abstract

Impaired renal function has been associated with an increased risk of thrombocytopenia in adults receiving linezolid. Findings from this retrospective cohort demonstrate an association between thrombocytopenia and lower creatinine clearance in children receiving linezolid.

Keywords: children; linezolid; pediatric; renal impairment; thrombocytopenia.

MeSH terms

Adolescent
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / adverse effects*
Anti-Bacterial Agents / pharmacokinetics
Child
Child, Preschool
Cohort Studies
Creatinine / blood*
Female
Humans
Infant
Linezolid / administration & dosage
Linezolid / adverse effects*
Linezolid / pharmacokinetics
Male
Platelet Count
Renal Insufficiency / chemically induced*
Retrospective Studies
Thrombocytopenia / chemically induced*

Substances

Anti-Bacterial Agents
Creatinine
Linezolid