The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma

J Neurosurg Pediatr. 2015 Dec;16(6):732-5. doi: 10.3171/2015.5.PEDS15142. Epub 2015 Sep 25.

Abstract

Intravenous administration of fluorescein sodium fluoresces glioma burden tissue and can be visualized using the surgical microscope with a specialized filter. Intraoperative guidance afforded through the use of fluorescein may enhance the fidelity of tissue sampling, and increase the ability to accomplish complete resection of tectal lesions. In this report the authors present the case of a 19-year-old man with a tectal anaplastic pilocytic astrocytoma in which the use of fluorescein sodium and a Zeiss Pentero surgical microscope equipped with a yellow 560 filter enabled safe complete resection. In conjunction with neurosurgical navigation, added intraoperative guidance provided by fluorescein may be beneficial in the resection of brainstem gliomas.

Keywords: anaplastic; fluorescein sodium; oncology; pilocytic astrocytoma; quadrigeminal plate lesion; tectal plate glioma.

Publication types

  • Case Reports

MeSH terms

  • Astrocytoma / metabolism
  • Astrocytoma / pathology
  • Astrocytoma / surgery*
  • Biopsy / methods*
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery*
  • Craniotomy / methods
  • Fluorescein / administration & dosage
  • Fluorescein / metabolism*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Microscopy / instrumentation
  • Microscopy / methods
  • Neoplasm Grading
  • Neuroendoscopy*
  • Tectum Mesencephali* / metabolism
  • Tectum Mesencephali* / pathology
  • Tectum Mesencephali* / surgery
  • Third Ventricle / surgery*
  • Tissue Distribution
  • Ventriculostomy / methods*
  • Young Adult

Substances

  • Fluorescein