Biocompatibility and characterization of polylactic acid/styrene-ethylene-butylene-styrene composites

Biomed Mater Eng. 2015:26 Suppl 1:S147-54. doi: 10.3233/BME-151300.

Abstract

Polylactic acid (PLA)/styrene-ethylene-butylene-styrene (SEBS) composites were prepared by melt blending. Differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WXRD) were used to characterize PLA and PLA/SEBS composites in terms of their melting behavior and crystallization. Curves from thermal gravimetric analysis (TGA) illustrated that thermostability increased with SEBS content. Further morphological analysis of PLA/SEBS composites revealed that SEBS molecules were not miscible with PLA molecules in PLA/SEBS composites. The tensile testing for PLA and PLA/SEBS composites showed that the elongation at the break was enhanced, but tensile strength decreased with increasing SEBS content. L929 fibroblast cells were chosen to assess the cytocompatibility; the cell growth of PLA was found to decrease with increasing SEBS content. This study proposes possible reasons for these properties of PLA/SEBS composites.

Keywords: Polylactic acid (PLA); biocompatibility; styrene-ethylene-butylene-styrene (SEBS); tensile property.

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / toxicity*
  • Cell Line
  • Cell Survival / drug effects*
  • Dose-Response Relationship, Drug
  • Elastic Modulus
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / physiology
  • Lactic Acid / chemistry*
  • Lactic Acid / toxicity
  • Materials Testing
  • Mice
  • Polyenes / chemistry
  • Polyenes / toxicity
  • Polyesters
  • Polyethylene / chemistry*
  • Polyethylene / toxicity
  • Polymers / chemistry*
  • Polymers / toxicity
  • Polystyrenes / chemistry*
  • Polystyrenes / toxicity
  • Stress, Mechanical
  • Tensile Strength

Substances

  • Biocompatible Materials
  • Polyenes
  • Polyesters
  • Polymers
  • Polystyrenes
  • Lactic Acid
  • poly(lactide)
  • Polyethylene
  • polybutene