Highly effective photodynamic inactivation of E. coli using gold nanorods/SiO2 core-shell nanostructures with embedded verteporfin

Chem Commun (Camb). 2015 Nov 25;51(91):16365-8. doi: 10.1039/c5cc06738c.

Abstract

The potential of gold nanorods post-coated with a 20 nm silica shell loaded with verteporfin (Au NRs@SiO2-VP) as efficient near-infrared nanostructures for photodynamic therapy under continuous wave and pulsed-mode excitation to eradicate a virulent strain of E. coli associated with urinary tract infection is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Escherichia coli / drug effects*
  • Gold / chemistry
  • Gold / pharmacology*
  • Nanotubes / chemistry*
  • Oxygen / chemistry
  • Photochemotherapy
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / chemistry
  • Porphyrins / pharmacology*
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / pharmacology*
  • Verteporfin

Substances

  • Anti-Bacterial Agents
  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin
  • Gold
  • Silicon Dioxide
  • Oxygen