Spinal cord injury-induced pain: mechanisms and treatments

Pain Manag. 2015;5(6):493-507. doi: 10.2217/pmt.15.47. Epub 2015 Sep 24.

Abstract

Pain is a common consequence of a spinal cord injury (SCI) and has a major impact on quality of life through its impact on physical function, mood and participation in work, recreational and social activities. Several types of pain typically present following SCI with central neuropathic pain being a frequent and difficult to manage occurrence. Despite advances in our understanding of the mechanisms contributing to this type of pain and an increasing number of trials examining treatment efficacy, our ability to relieve neuropathic SCI pain is still very limited. Optimal management relies upon an integrated approach that uses a combination of pharmacological and nonpharmacological options.

Keywords: CNS; management; neuropathic; pain; spinal cord injuries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology
  • Humans
  • Neuralgia / therapy*
  • Pain / etiology*
  • Pain / physiopathology
  • Pain Management*
  • Quality of Life
  • Spinal Cord / physiopathology
  • Spinal Cord Injuries / complications*
  • Spinal Cord Injuries / physiopathology
  • Treatment Outcome