Fluorescent supramolecular polypseudorotaxane architectures with Ru(II)/tri(bipyridine) centers as multifunctional DNA reagents

Wen Zhang; Heng-Yi Zhang; Yu-Hui Zhang; Yu Liu

doi:10.1039/c5cc07216f

Fluorescent supramolecular polypseudorotaxane architectures with Ru(II)/tri(bipyridine) centers as multifunctional DNA reagents

Chem Commun (Camb). 2015 Nov 18;51(89):16127-30. doi: 10.1039/c5cc07216f.

Authors

Wen Zhang¹, Heng-Yi Zhang², Yu-Hui Zhang¹, Yu Liu²

Affiliations

¹ Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China. hyzhang@nankai.edu.cn.
² Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China. hyzhang@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.

PMID: 26396998
DOI: 10.1039/c5cc07216f

Abstract

A water-soluble supramolecular polypseudorotaxane was prepared via the host-guest interaction of cucurbit[8]uril and the Ru(bpy)3 complex with bis-naphthalene groups. By employing the intrinsic properties of the Ru(bpy)3 complex, the linear polypseudorotaxane can induce DNA condensation, be used as an inhibitor for DNA cleavage enzymes, and trace the translocation of DNA into 293T cells efficiently.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2,2'-Dipyridyl / chemistry*
Coordination Complexes / chemistry*
DNA / chemistry*
Electrophoresis, Agar Gel
Fluorescent Dyes / chemistry*
Microscopy, Atomic Force
Molecular Structure
Polymers / chemical synthesis
Polymers / chemistry
Rotaxanes / chemistry*
Ruthenium / chemistry*
Solubility
Water / chemistry

Substances

Coordination Complexes
Fluorescent Dyes
Polymers
Rotaxanes
Water
2,2'-Dipyridyl
Ruthenium
DNA