In Vitro Modeling of Brain Progenitor Cell Development under the Effect of Environmental Factors

N V Kuvacheva; A V Morgun; Yu K Komleva; E D Khilazheva; Ya V Gorina; O L Lopatina; S A Arutyunyan; A B Salmina

doi:10.1007/s10517-015-3012-8

In Vitro Modeling of Brain Progenitor Cell Development under the Effect of Environmental Factors

Bull Exp Biol Med. 2015 Aug;159(4):546-9. doi: 10.1007/s10517-015-3012-8. Epub 2015 Sep 22.

Authors

N V Kuvacheva¹, A V Morgun², Yu K Komleva², E D Khilazheva², Ya V Gorina², O L Lopatina², S A Arutyunyan³, A B Salmina²

Affiliations

¹ V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia. natalya.kuvacheva@gmail.com.
² V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
³ Siberian State Technological University, Krasnoyarsk, Russia.

PMID: 26395632
DOI: 10.1007/s10517-015-3012-8

Abstract

We studied in vitro development of brain progenitor cells isolated from healthy 7-9-month-old Wistar rats and rats with experimental Alzheimer's disease kept under standard conditions and in enriched (multistimulus) environment in vivo. Progenitor cells from healthy animals more rapidly formed neurospheres. Considerable changes at the early stages of in vitro development of brain progenitor cells were observed in both groups kept in enriched environment.

Keywords: enriched environment; neurogenesis; progenitor cells.

MeSH terms

Alzheimer Disease / pathology
Animals
Brain / pathology
Cell Proliferation
Cells, Cultured
Environment
Environment Design
Housing, Animal
Neural Stem Cells / physiology*
Rats, Wistar