The pluripotent state in mouse and human

Kathryn C Davidson; Elizabeth A Mason; Martin F Pera

doi:10.1242/dev.116061

The pluripotent state in mouse and human

Development. 2015 Sep 15;142(18):3090-9. doi: 10.1242/dev.116061.

Authors

Kathryn C Davidson¹, Elizabeth A Mason², Martin F Pera³

Affiliations

¹ Centre for Eye Research Australia, University of Melbourne, and Royal Victorian Eye and Ear Hospital, Melbourne 3002, Victoria, Australia.
² Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Brisbane 4072, Australia Department of Anatomy and Neuroscience, University of Melbourne, Melbourne 3010, Victoria, Australia.
³ Department of Anatomy and Neuroscience, University of Melbourne, Melbourne 3010, Victoria, Australia The Florey Institute of Neuroscience and Mental Health and Walter Elisa Hall Institute of Medical Research, Parkville 3052, Victoria, Australia mpera@unimelb.edu.au.

PMID: 26395138
DOI: 10.1242/dev.116061

Abstract

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the pre-implantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naïve PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.

Keywords: Human; Mouse; Pluripotent state.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Blastocyst / cytology
Blastocyst / physiology*
Cell Lineage / physiology*
Embryonic Development / physiology*
Epigenesis, Genetic / physiology*
Gene Expression Regulation, Developmental / physiology*
Germ Layers / cytology*
Humans
Mice
Pluripotent Stem Cells / cytology*
Species Specificity