Abstract
Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1 -weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m(-1) s(-1) ), and achieves the real-time monitoring of drug release.
Keywords:
Prussian blue; magnetic resonance imaging; manganese; pH-responsive; theranostics.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Cell Survival / drug effects
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Contrast Media / chemistry*
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Doxorubicin / chemistry
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Doxorubicin / metabolism
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Doxorubicin / toxicity
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Drug Carriers / chemistry
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Drug Liberation
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Ferrocyanides / chemistry*
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Humans
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Hydrogen-Ion Concentration
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Magnetic Resonance Imaging
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Manganese Compounds / chemistry
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Nanoparticles / chemistry*
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Nanoparticles / ultrastructure
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Oxides / chemistry
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Porosity
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / metabolism
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Silicon Dioxide / chemistry
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Theranostic Nanomedicine
Substances
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Antineoplastic Agents
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Contrast Media
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Drug Carriers
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Ferrocyanides
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Manganese Compounds
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Oxides
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RNA, Small Interfering
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manganese oxide
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Silicon Dioxide
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Doxorubicin
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ferric ferrocyanide