A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity

Adv Mater. 2015 Nov 4;27(41):6382-9. doi: 10.1002/adma.201503381. Epub 2015 Sep 22.

Abstract

Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1 -weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m(-1) s(-1) ), and achieves the real-time monitoring of drug release.

Keywords: Prussian blue; magnetic resonance imaging; manganese; pH-responsive; theranostics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Contrast Media / chemistry*
  • Doxorubicin / chemistry
  • Doxorubicin / metabolism
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry
  • Drug Liberation
  • Ferrocyanides / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging
  • Manganese Compounds / chemistry
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Oxides / chemistry
  • Porosity
  • RNA, Small Interfering / chemistry
  • RNA, Small Interfering / metabolism
  • Silicon Dioxide / chemistry
  • Theranostic Nanomedicine

Substances

  • Antineoplastic Agents
  • Contrast Media
  • Drug Carriers
  • Ferrocyanides
  • Manganese Compounds
  • Oxides
  • RNA, Small Interfering
  • manganese oxide
  • Silicon Dioxide
  • Doxorubicin
  • ferric ferrocyanide