Abstract
Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.
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MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Azabicyclo Compounds / pharmacology*
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Aztreonam / pharmacology*
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Bacterial Proteins / classification
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Ceftazidime / pharmacology*
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Colistin / pharmacology
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Drug Combinations
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Enterobacteriaceae / growth & development
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Fosfomycin / pharmacology
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Gene Expression
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Humans
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Microbial Sensitivity Tests
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Minocycline / analogs & derivatives
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Minocycline / pharmacology
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Tigecycline
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beta-Lactamases / classification
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Azabicyclo Compounds
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Bacterial Proteins
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Drug Combinations
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avibactam, ceftazidime drug combination
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Fosfomycin
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Tigecycline
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avibactam
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Ceftazidime
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beta-Lactamases
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carbapenemase
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Minocycline
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Aztreonam
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Colistin