Lack of association of the iNOS gene polymorphism with risk of cancer: a systematic review and Meta-Analysis

Jinghua Jiao; Jingyang Wu; Desheng Huang; Lei Liu

doi:10.1038/srep09889

Lack of association of the iNOS gene polymorphism with risk of cancer: a systematic review and Meta-Analysis

Sci Rep. 2015 Sep 22:5:9889. doi: 10.1038/srep09889.

Authors

Jinghua Jiao¹, Jingyang Wu², Desheng Huang³, Lei Liu^{2

3}

Affiliations

¹ Department of Anesthesiology, Central Hospital, Shenyang Medical College. Shenyang, 110024, China.
² Department of Ophthalmology, The First Affiliated Hospital, China Medical University. Shenyang, 110001, China.
³ Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, China.

Abstract

In order to investigate the association between the iNOS gene polymorphisms and susceptibility to cancer, a search of English papers was done using Pubmed, the Cochrane Library, Embase, ISI Web of Science, Google (scholar) database, and all Chinese reports were conducted using CBMDisc, Chongqing VIP database, and CNKI database. A total of eight studies were included in this meta-analysis including 1,920 cases and 2,373 controls. The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models. This meta-analysis suggested that the polymorphisms in the iNOS gene were not associated with cancer risk.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Alleles
Case-Control Studies
Genetic Association Studies
Genetic Predisposition to Disease*
Genotype
Humans
Neoplasms / genetics*
Nitric Oxide Synthase Type II / genetics*
Odds Ratio
Polymorphism, Genetic*
Polymorphism, Single Nucleotide

Substances

Nitric Oxide Synthase Type II